Jak2 CLIA Kit for Mouse(Mus musculus) | EIAab.comJak2 CLIA Kit for Mouse(Mus musculus)

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Jak2 (Gene name),

Tyrosine-protein kinase JAK2 (Protein name ), JAK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Jak2;

Protein name:

Tyrosine-protein kinase JAK2;

Alternative:

Janus kinase 2(JAK-2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with EPOR, SIRPA, SH2B1 and TEC.

Function:

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Subcellular Location:

Endomembrane system Peripheral membrane protein Cytoplasm Nucleus

Protein Attributes:

Sequence length:

1129

Sequence:

50:

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250:

300:

350:

400:

450:

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750:

800:

850:

900:

950:

1000:

1050:

1100:

1129:

IMTECWNNNV | SQRPSFRDLS | LRVDQIIAA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07714

SMR:

Q62120

UniGene:

Mm.275839

String:

Q62120

KEGG:

mmu:16452

Uniprot:

Q62120

FOR

ELISA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

E9140h

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96T

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ELISA Kit for Mouse Tyrosine-protein kinase JAK2

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ELISA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

E9140m

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ELISA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

E9140r

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ELISA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

E9140p

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Packing:

96T

CLIA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

U9140r

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96T

CLIA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

U9140m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Tyrosine-protein kinase JAK2

MSDS:

Please sign in first.

CLIA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

U9140h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Tyrosine-protein kinase JAK2

Cat.:

U9140p

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK2

Cat.:

P9140Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK2

Cat.:

P9140Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse Tyrosine-protein kinase JAK2

Protein for Mouse Tyrosine-protein kinase JAK2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction."
Silvennoinen O. , Witthuhn B.A. , Quelle F.W. , Cleveland J.L. , Yi T. , Ihle J.N.
Proc. Natl. Acad. Sci. U.S.A.90:8429-8433(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
3.

"The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family."
Wilks A.F. , Kurban R.R. , Hovens C.M. , Ralph S.J.
Gene85:67-74(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 973-1043
4.

"Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction."
Wilks A.F.
Proc. Natl. Acad. Sci. U.S.A.86:1603-1607(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 973-1043
5.

"JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin."
Witthuhn B.A. , Quelle F.W. , Silvennoinen O. , Yi T. , Tang B. , Miura O. , Ihle J.N.
Cell74:227-236(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPOR
6.

"The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain."
Zhao Y. , Wagner F. , Frank S.J. , Kraft A.S.
J. Biol. Chem.270:13814-13818(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CYTOKINE/INTERFERON/GROWTH HORMONE RECEPTORS
7.

"An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells."
Nakamura N. , Chin H. , Miyasaka N. , Miura O.
J. Biol. Chem.271:19483-19488(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF STAT5A AND STAT5B
8.

"Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription."
Yamashita Y. , Watanabe S. , Miyazato A. , Ohya K. , Ikeda U. , Shimada K. , Komatsu N. , Hatake K. , Miura Y. , Ozawa K. , Mano H.
Blood91:1496-1507(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY TEC
9.

"Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway."
Chin H. , Arai A. , Wakao H. , Kamiyama R. , Miyasaka N. , Miura O.
Blood91:3734-3745(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN
10.

"Jak2 is essential for signaling through a variety of cytokine receptors."
Parganas E. , Wang D. , Stravopodis D. , Topham D.J. , Marine J.C. , Teglund S. , Vanin E.F. , Bodner S. , Colamonici O.R. , van Deursen J.M. , Grosveld G. , Ihle J.N.
Cell93:385-395(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
11.

"Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis."
Neubauer H. , Cumano A. , Muller M. , Wu H. , Huffstadt U. , Pfeffer K.
Cell93:397-409(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
12.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure."
Guilluy C. , Bregeon J. , Toumaniantz G. , Rolli-Derkinderen M. , Retailleau K. , Loufrani L. , Henrion D. , Scalbert E. , Bril A. , Torres R.M. , Offermanns S. , Pacaud P. , Loirand G.
Nat. Med.16:183-190(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha."
Stofega M.R. , Argetsinger L.S. , Wang H. , Ullrich A. , Carter-Su C.
J. Biol. Chem.275:28222-28229(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRPA
15.

"The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor."
Huang L.J. , Constantinescu S.N. , Lodish H.F.
Mol. Cell8:1327-1338(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPOR
16.

"Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2."
Funakoshi-Tago M. , Pelletier S. , Matsuda T. , Parganas E. , Ihle J.N.
EMBO J.25:4763-4772(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-119;MUTAGENESIS OF TYR-119
17.

"SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms."
Li Z. , Zhou Y. , Carter-Su C. , Myers M.G. Jr. , Rui L.
Mol. Endocrinol.21:2270-2281(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B1;PHOSPHORYLATION AT TYR-813
18.

"Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity."
Argetsinger L.S. , Stuckey J.A. , Robertson S.A. , Koleva R.I. , Cline J.M. , Marto J.A. , Myers M.G. Jr. , Carter-Su C.
Mol. Endocrinol.24:1062-1076(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-868; TYR-966; TYR-972 AND TYR-1008;MUTAGENESIS OF TYR-868; TYR-966; TYR-972 AND TYR-1008
19.

"Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation."
Sayyah J. , Gnanasambandan K. , Kamarajugudda S. , Tsuda S. , Caldwell-Busby J. , Sayeski P.P.
Cell. Signal.23:1806-1815(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-372 AND TYR-373;MUTAGENESIS OF TYR-372 AND TYR-373
20.

"Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control."
Jakel H. , Weinl C. , Hengst L.
Oncogene30:3502-3512(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDKN1B
21.

"Jak2: normal function and role in hematopoietic disorders."
Ihle J.N. , Gilliland D.G.
Curr. Opin. Genet. Dev.17:8-14(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
22.

"Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS."
Hu J. , Hubbard S.R.
J. Mol. Biol.361:69-79(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 810-820 IN COMPLEX WITH SH2B1;PHOSPHORYLATION AT TYR-813

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